MACSI Saskatoon Centre is one of the leading addiction treatment centers in the city. Their mission is to empower individuals to make healthy choices in their communities through a continuum of addictions services, including education, treatment and aftercare to restore a balanced, harmonious, and productive lifestyle. They recognize the needs of families and their critical role in supporting people with mental health and addiction problems. They believe in understanding and helping the whole person in ways that are holistic and focused on recovery and believe that treating people with respect is a key guiding principle for any effective and healthy organization. It also offers individualized treatment, hope and empowerment through inpatient treatment plans, providing a 28-day residential option for adults. They also provide both online counselling and telephone counselling.

Possibilities Recovery Center Inc is Saskatchewan's first intensive Outpatient Addiction Treatment Center. They offer Pre-treatment programming for people waiting to get into inpatient treatment. Their mission is to provide opportunities for recovery from mental health and substance use disorders and to promote positive change in not only the life of the person living with substance use but their families as well. Their 16-week intensive Outpatient program works in place of inpatient treatment. Possibilities Recovery Center Inc will provide its clients with an unparalleled holistic addictions program experience. They always make their patients feel happy and healthy through their service.

Calder Centre is one of the best addiction treatment centers in the city. They offer Calder Centre Adult Program, which is a 38-bed inpatient program providing a safe, supportive environment to help individuals with substance use/abuse through the stabilization tasks of recovery. It uses the biological, psychological, social, and spiritual understanding of addiction and recovery. Calder Centre does not offer detox services for adults. The program is based on a four week residential stay but offers flexibility to shorten or extend the length of stay depending on the individual's needs. They also provide a gender-specific treatment based on research that indicates males and females differ in onset, consequences and recovery from substance use/abuse. All their programming includes counselling and education on substance use/abuse. It is group based and provides competency-based treatment to match individualized treatment goals. Their facilities are open 24 hours a day.